Battle of Issus was second major battle of Alexander the Great during his campaign in Asia. After defeat ini Battle of the Granicus Darius III decided to lead his army personally, he gathered enough forces and met the Macedonians near the Pinarus River and the town of Issus. Since the Persians had advantage in numbers (48,000 Macedonians against almost 100,000 Persians) Alexander prepared the battleplan that involved attacking straight on the position of Darius and aiming to kill him as fast as possible, thus cutting off the head of the whole army. His plan worked well and in the face of danger Darius fled the battlefield leaving behind his generals, all of which have died that day. This battle gave Alexander the Great the control over Asia Minor and put Darius in difficult position.
Story of Alexander the Great and his campaing to Asia - from the first battle to the ruling of almost whole world known to anscient geography.